Altered cancer cell metabolism and cachexia: Calculating the energetic cost of cancer

Methods and Results We model an anaerobic component of tumor energy metabolism to assess its impact and contribution to cachexia. In this model, with a high level of anaerobic energy production, the energetic cost to sustain the tumor may reach or exceed 394 kcal/ day per kg of tumor. In addition, the tumor’s high level of glucose and glutamine consumption causes muscle breakdown to fuel the tumor, especially in the fasting state. We calculate an estimate of the tumor’s energetic cost on the body in terms of aerobic and anaerobic components, as well as the Cori cycling cost of recycling lactate generated by the tumor back into glucose, at varying levels of tumor mass and of anaerobic energy metabolism.